Andrea Cupp

Reproductive Physiologist, Beef Physiologist
Irvin T. and Wanda R. Omtvedt Professor of Animal Science

Ph.D., Repro Endo/Animal Science, University of Nebraska-Lincoln, 1994
M.S., Repro Endo/Animal Science, University of Nebraska-Lincoln, 1991
B.S., Animal Science, Virginia Tech, 1988

Dr. Andrea Cupp joined the Department of Animal Science in 2000 and currently serves as the Irvin T. and Wanda R. Omtvedt Professor of Animal Science in reproductive physiology in beef cattle. She earned her B.A. in Biology from Virginia Tech, before earning her M.S., and Ph.D., in Reproductive Endocrinology and Animal Science from University of Nebraska-Lincoln.

Dr. Cupp's research interests include the effects of both vascular development on gonadal morphogenesis and of vascular development on follicle progression and ovulation. She also does collaborative research on both the effects of nutrition on reproductive function in cattle and of hormones and environment on oocyte quality.


  • ASCI 442/842:Endocrinology
    Semester: Fall
    Summary: This course will review hormonal regulation and function of endocrine systems at both a molecular and whole-animal level. The lectures in class(after a general introduction) will concentrate on each organ, the hormones that it produces, and how its function may be integrated at the systemic and cellular level. The specific biological systems we will be addressing are hormones that regulate growth, stress, metabolism, reproduction, and diseases associated with these processes. The discussion and lectures in class will utilize several different endocrine systems in animal species and relate them to humans as applicable.
  • ASCI 845/645
    Summary: Primarily mammalian physiology with discussion of cellular mechanisms designed for students in animal and biological sciences or veterinary medicine. Topics include microscopic anatomy and physiology of cells, tissues, cardiovascular system, respiratory system, and urinary system.


  • Abedal-Majed, MA, AS Cupp. Livestock Animals to Study Infertility in Women. Animal Frontiers 2019 July;9(3):28-33. doi: 10.1093/af/vfz017.
  • Plewes, MR, X Hou, P Zhang, JR Wood, AS Cupp, X Lv, C Wang, and JS Davis. Yes-associated protein (YAP) is required for proliferation and function of bovine granulosa cells. Biol Reprod. 2019 Jul 27. pii: ioz139. doi: 10.1093/biolre/ioz139.
  • Abedel-Majed MA, Romereim SM, Davis JS, Cupp AS. Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function. Front Endocrinol (Lausanne). 2019 Nov 29;10:832. doi: 10.3389/fendo.2019.00832. eCollection 2019. Review.
  • Abedal-Majed, MA, SG Kurz; AS Springman, AK. McNeel; HC Freetly, V Largen; M Magamage; KM Sargent; JR Wood, RA Cushman; AS Cupp. Vascular Endothelial Growth Factor A isoforms modulate follicle fate independent of diet through diverse signal transduction pathways. Biol Reprod. 2020 Mar 13;102(3):680-692. doi: 10.1093/biolre/ioz211.
  • Plewes MR, Hou X, Talbott HA, Zhang P, Wood JR, Cupp AS, Davis JS. Luteinizing hormone regulates the phosphorylation and localization of the mitochondrial effector dynamin-related protein-1 (DRP1) and steroidogenesis in the bovine corpus luteum. FASEB J. 2020 Feb 20. doi: 10.1096/fj.201902958R.
  • Plewes MR, Krause C, Talbott HA, Przygrodzka E, Wood JR, Cupp AS, Davis JS. Trafficking of cholesterol from lipid droplets to mitochondria in bovine luteal cells: Acute control of progesterone synthesis. FASEB J. 2020 Aug;34(8):10731-10750. doi: 10.1096/fj.202000671R. Epub 2020 Jul 2.
  • Talbott HA, Plewes MR, Krause C, Hou X, Zhang P, Rizzo WB, Wood JR, Cupp AS, Davis JS. Formation and characterization of lipid droplets of the bovine corpus luteum. Sci Rep. 2020 Jul 9;10(1):11287. doi: 10.1038/s41598-020-68091-2. PMID: 32647143.
  • Sutton, C.M., Springman, S.A., Abedal-Majed, M.A., Cupp, A.S. Bovine Ovarian Cortex Tissue Culture. J. Vis. Exp. (167), e61668, doi:10.3791/61668 (2021).
  • Nafziger, SR, SC Tenley, AF. Summers, MA. Abedal-Majed, M Hart, J Bergman, SG Kurz, JS Davis, JR Wood, AS Cupp. Attainment and Maintenance of Pubertal Cyclicity May Predict Reproductive Longevity in Beef Heifers. Biol Reprod. 2021 Mar 11:ioab044. doi: 10.1093/biolre/ioab044.
  • McFee, RM, SM Romereim, AP Snider, AF Summers, WE Pohlmeier, SG Kurz, JS Davis, JR Wood, AS Cupp. A High-Androgen Microenvironment Inhibits Granulosa Cell Proliferation and Alters Cell Identity. Molecular and Cellular Endocrinology 2021 April
  • Snider AP, SM Romereim, RM McFee, AF Summers, WE Pohlmeier, SG Kurz, JS Davis, JR Wood, AS Cupp. Transcriptomes of bovine ovarian granulosa cells of control and High A4 cows. Data Brief. 2021 Jun 11;37:107217. doi: 10.1016/j.dib.2021.107217. eCollection 2021 Aug.
  • Przygrodzka E, Monaco CF, Plewes MR, Li G, Wood JR, Cupp AS, Davis JS. Protein Kinase A and 5' AMP-Activated Protein Kinase Signaling Pathways Exert Opposite Effects on Induction of Autophagy in Luteal Cells. Front Cell Dev Biol. 2021 Nov 8;9:723563. doi: 10.3389/fcell.2021.723563. eCollection 2021. PMID: 34820368.
  • Abedal-Majed MA, Springman SA, Sutton CM, Snider AP, Bell BE, Hart M, Kurz SG, Bergman J, Summers AF, McFee RM, Davis JS, Wood JR, Cupp AS. VEGFA165 can rescue excess steroid secretion, inflammatory markers and follicle arrest in the ovarian cortex of high A4 cows. Biol Reprod. 2022 Jan 13;106(1):118-131. doi: 10.1093/biolre/ioab201.
  • Rowell JE, Blake JE, Roth KM, Sutton CM, Sachse CC, Cupp AS, Geary TW, Zezeski AL, Alexander BM, Ziegler RL, Shipka MP. J Medroxyprogesterone acetate in reindeer bulls: testes histology, cfos activity in the brain, breeding success and semen quality. J Anim Sci. 2022 Jun 1;100(6):skac106. doi: 10.1093/jas/skac106.
  • Abedal-Majed MA, Springman SA, Jafar HD, Bell BE, Kurz SG, Wilson KE, Cupp AS. Naturally occurring androgen excess cows are present in Dairy and Beef Herds and have similar characteristics to women with PCOS. J Anim Sci. 2022 Jun 1;100(6):skac151. doi: 10.1093/jas/skac151.
  • Bott, RC, DT Clopton, AS Cupp. A Proposed Role for VEGF Isoforms in Sex-Specific Vasculature Development in the Gonad. (2008) In Press; Reproduction in Domestic Animals.
  • Harris HL, Cupp AS, Roberts AJ, Funston RN. Utilization of soybeans or corn milling byproducts in beef heifer development diets. J Anim Sci. 2007 Oct 16: (Epub ahead of print).
  • Martin JL, Cupp AS, Rasby RJ, Hall ZC, Funston RN. Utilization of dried distillers grains for developing beef heifers. J. Anim Sci. 2007: Sep 85(9): 2298-303. Epub 2007 May 25.
  • Bott RC, McFee, R M, DT Clopton, CF Toombs and AS Cupp. Vascular Endothelial Growth Factor (VEGFA) and Kinase Domain Region Receptor Are Involved in Both Seminiferous Cord Formation and Vascular development During Testis Morphogenesis in the Rat. Biol Reprod. 2006 Aug; 75:56-67.
  • Anaway MD, AS Cupp, M Uzumcu, MK Skinner. Epigenetic Transgenerational Actions of Endocrine Disruptors on Male Fertility. Science 2005, June 3: 308: 1466-1469.
  • Cupp AS , M Uzumcu, H Suzuki, K Dirks, B Phillips, MK Skinner. Effect of Transient embryonic in vivo exposure to the endocrine disruptor methoxychlor on embryonic and postnatal development. J Androl 2003; 24:736-745.
  • Kojima FN, Bergfeld EG, Wehrman ME, Cupp AS, Fike KE, Mariscal-Aguayo DV, Sanchez-Torres T, Garcia-Winder M, Clopton DT, Roberts AJ, Kinder JE. Frequency of luteinizing hormone pulses in cattle influences duration of persistence of dominant ovarian follicles, follicular fluid concentrations of steroids, and activity of insulin-like growth factor binding proteins. Animal Reproduction Science. 77(3-4): 187-211, Jul 2003.
  • Cupp AS , Uzumcu M, MK Skinner. Chemotactic role of Neurotrophin 3 in the embryonic testis that facilitates male sex determination. Biol. Reprod. 2003 Jun;68(6):2033-7.
  • Cupp AS , L Tessarollo, and MK Skinner. Testis development phenotypes in neurotrophin receptor trkA and trkC null mutations: Role in seminiferous cord formation and germ cell survival. Biol. Reprod. 2002;66:1838-1845.
  • Cupp AS G Kim, and MK Skinner. Expression and action of Transforming Growth Factor-alpha on embryonic testis growth and development. J. Andrology 2001; 22:1019-1029.
  • Cupp AS and Skinner MK. Actions of the endocrine disruptor methoxychlor and its estrogenic metabolite on embryonic seminiferous cord formation and perinatal testis growth. Repro Toxicol 2001; 15:317-326.
photo of Andrea Cupp
Areas of Expertise
Beef Cattle

Professional Highlights

Honors and Recognition
2006 - Society for the Study of Reproduction; Young Investigator Award
2006 - Outstanding Young Researcher Award; Midwest Section of ASAS/ADSA
2005 - Named to Editorial Board, RURALS- Review of Undergraduate Research in Agricultural and Life Sciences
2005 - Named Associate Editor, Renewable Agriculture and Food Systems
2004 - University of Nebraska - Lincoln Agriculture Research Division Junior Faculty Excellence in Research Award
2003 - Named to Editorial Board, Journal of Animal Science
1995 - USDA Postdoctoral Fellowship Grant
1990 & 1993 - Arthaud Memorial Travel Fellowship, University of Nebraska-Lincoln
1992 - Milton E. Moore Biotechnology Fellowship, University of Nebraska-Lincoln
1992 - Women's Research Institute Reproductive Colliculum Travel Grant
1992 - Society for the Study of Reproduction Trainee Travel Fellowship
1991 - Sigma Xi Travel Fellowship, University of Nebraska-Lincoln
1990 - Center for Biotechnology Associateship, University of Nebraska-Lincoln
1987 - Rocco Student Leader Scholarship, Virginia Tech
January 2011-Present - Professor, University of Nebraska-Lincoln
July 2006-2011 - Associate Professor, University of Nebraska-Lincoln
2000-2006 - Assistant Professor, University of Nebraska-Lincoln
1999-2000 - Adjunct Professor, Washington State University
January-August 2000 - Dir. Trans Mouse Core, Washington State University
1998-1999 - Research Assistant Professor, Washington State University
1996-1997 - USDA Post-doc Fellow, Washington State University
1994-1996 - USDA Post-doc Fellow, University Cal-San Francisco
Society for the Study of Reproduction
American Society of Animal Science
American Society of Andrology
American Association for the Advancement of Science
Nebraska Physiological Society
Sigma Xi
Gamma 1990-94, 2004-Present - Sigma Delta, University of Nebraska
1998-2000 - Center for Reproductive Biology, Washington State University