Andrea Cupp

Ph.D., Repro Endo/Animal Science, University of Nebraska-Lincoln, 1994
M.S., Repro Endo/Animal Science, University of Nebraska-Lincoln, 1991
B.S., Animal Science, Virginia Tech, 1988

Dr. Andrea Cupp joined the Department of Animal Science in 2000 and currently serves as the Irvin T. and Wanda R. Omtvedt Professor of Animal Science in reproductive physiology in beef cattle. She earned her B.S. in Animal Science from Virginia Tech, before earning her M.S., and Ph.D., in Reproductive Endocrinology and Animal Science from University of Nebraska-Lincoln.

Dr. Cupp's research interests include using Animal models- Beef Cattle, and rodents, to understand how ovarian environment affects follicle development and female fertility. Her lab is also interested in how females attain puberty and their reproductive health throughout their lifespan.

COURSES

• ASCI 442/842:Endocrinology
  Semester: Fall
  Summary: This course will review hormonal regulation and function of endocrine systems at both a molecular and whole-animal level. The lectures in class (after a general introduction) will concentrate on each organ, the hormones that it produces, and how its function may be integrated at the systemic and cellular level. The specific biological systems we will be addressing are hormones that regulate growth, stress, metabolism, reproduction, and diseases associated with these processes. The discussion and lectures in class will utilize several different endocrine systems in animal species and relate them to humans as applicable. We will utilize many different case studies which students will present to the class in order for them to understand how to work in teams and how to solve problems related to endocrine disorders.
• ASCI 896-003
  Semester: Even Year, Spring Semesters
  Summary: This course is taught on even years in the Spring Semester and allows graduate students to learn how to write and develop a grant including budgets. Many students that have taken this class have submitted and received federal pre and postdoctoral grants, state funded grants through many different agencies, and have used their grants as their doctoral comprehensive exam. The class is capped at 10 students.

SELECTED PUBLICATIONS

• Abedal-Majed, MA, AS Cupp. Livestock Animals to Study Infertility in Women. Animal Frontiers 2019 July;9(3):28-33. doi: 10.1093/af/vfz017.
• Plewes, MR, X Hou, P Zhang, JR Wood, AS Cupp, X Lv, C Wang, and JS Davis. Yes-associated protein (YAP) is required for proliferation and function of bovine granulosa cells. Biol Reprod. 2019 Jul 27. pii: ioz139. doi: 10.1093/biolre/ioz139.
• Abedel-Majed MA, Romereim SM, Davis JS, Cupp AS. Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function. Front Endocrinol (Lausanne). 2019 Nov 29;10:832. doi: 10.3389/fendo.2019.00832. eCollection 2019. Review.
• Abedal-Majed, MA, SG Kurz; AS Springman, AK. McNeel; HC Freetly, V Largen; M Magamage; KM Sargent; JR Wood, RA Cushman; AS Cupp. Vascular Endothelial Growth Factor A isoforms modulate follicle fate independent of diet through diverse signal transduction pathways. Biol Reprod. 2020 Mar 13;102(3):680-692. doi: 10.1093/biolre/ioz211.
• Plewes MR, Hou X, Talbott HA, Zhang P, Wood JR, Cupp AS, Davis JS. Luteinizing hormone regulates the phosphorylation and localization of the mitochondrial effector dynamin-related protein-1 (DRP1) and steroidogenesis in the bovine corpus luteum. FASEB J. 2020 Feb 20. doi: 10.1096/fj.201902958R.
• Plewes MR, Krause C, Talbott HA, Przygrodzka E, Wood JR, Cupp AS, Davis JS. Trafficking of cholesterol from lipid droplets to mitochondria in bovine luteal cells: Acute control of progesterone synthesis. FASEB J. 2020 Aug;34(8):10731-10750. doi: 10.1096/fj.202000671R. Epub 2020 Jul 2.
• Talbott HA, Plewes MR, Krause C, Hou X, Zhang P, Rizzo WB, Wood JR, Cupp AS, Davis JS. Formation and characterization of lipid droplets of the bovine corpus luteum. Sci Rep. 2020 Jul 9;10(1):11287. doi: 10.1038/s41598-020-68091-2. PMID: 32647143.
• Sutton, C.M., Springman, S.A., Abedal-Majed, M.A., Cupp, A.S. Bovine Ovarian Cortex Tissue Culture. J. Vis. Exp. (167), e61668, doi:10.3791/61668 (2021).
• Nafziger, SR, SC Tenley, AF. Summers, MA. Abedal-Majed, M Hart, J Bergman, SG Kurz, JS Davis, JR Wood, AS Cupp. Attainment and Maintenance of Pubertal Cyclicity May Predict Reproductive Longevity in Beef Heifers. Biol Reprod. 2021 Mar 11:ioab044. doi: 10.1093/biolre/ioab044.
• McFee, RM, SM Romereim, AP Snider, AF Summers, WE Pohlmeier, SG Kurz, JS Davis, JR Wood, AS Cupp. A High-Androgen Microenvironment Inhibits Granulosa Cell Proliferation and Alters Cell Identity. Molecular and Cellular Endocrinology 2021 April https://doi.org/10.1016/j.mce.2021.111288.

• Snider AP, SM Romereim, RM McFee, AF Summers, WE Pohlmeier, SG Kurz, JS Davis, JR Wood, AS Cupp. Transcriptomes of bovine ovarian granulosa cells of control and High A4 cows. Data Brief. 2021 Jun 11;37:107217. doi: 10.1016/j.dib.2021.107217. eCollection 2021 Aug.

• Przygrodzka E, Monaco CF, Plewes MR, Li G, Wood JR, Cupp AS, Davis JS. Protein Kinase A and 5' AMP-Activated Protein Kinase Signaling Pathways Exert Opposite Effects on Induction of Autophagy in Luteal Cells. Front Cell Dev Biol. 2021 Nov 8;9:723563. doi: 10.3389/fcell.2021.723563. eCollection 2021. PMID: 34820368.
• Abedal-Majed MA, Springman SA, Sutton CM, Snider AP, Bell BE, Hart M, Kurz SG, Bergman J, Summers AF, McFee RM, Davis JS, Wood JR, Cupp AS. VEGFA165 can rescue excess steroid secretion, inflammatory markers and follicle arrest in the ovarian cortex of high A4 cows. Biol Reprod. 2022 Jan 13;106(1):118-131. doi: 10.1093/biolre/ioab201.
• Rowell JE, Blake JE, Roth KM, Sutton CM, Sachse CC, Cupp AS, Geary TW, Zezeski AL, Alexander BM, Ziegler RL, Shipka MP. J Medroxyprogesterone acetate in reindeer bulls: testes histology, cfos activity in the brain, breeding success and semen quality. J Anim Sci. 2022 Jun 1;100(6):skac106. doi: 10.1093/jas/skac106.
• Abedal-Majed MA, Springman SA, Jafar HD, Bell BE, Kurz SG, Wilson KE, Cupp AS. Naturally occurring androgen excess cows are present in Dairy and Beef Herds and have similar characteristics to women with PCOS. J Anim Sci. 2022 Jun 1;100(6):skac151. doi: 10.1093/jas/skac151.

• Bott, RC, DT Clopton, AS Cupp. A Proposed Role for VEGF Isoforms in Sex-Specific Vasculature Development in the Gonad. (2008) In Press; Reproduction in Domestic Animals.
• Harris HL, Cupp AS, Roberts AJ, Funston RN. Utilization of soybeans or corn milling byproducts in beef heifer development diets. J Anim Sci. 2007 Oct 16: (Epub ahead of print).
• Martin JL, Cupp AS, Rasby RJ, Hall ZC, Funston RN. Utilization of dried distillers grains for developing beef heifers. J. Anim Sci. 2007: Sep 85(9): 2298-303. Epub 2007 May 25.
• Bott RC, McFee, R M, DT Clopton, CF Toombs and AS Cupp. Vascular Endothelial Growth Factor (VEGFA) and Kinase Domain Region Receptor Are Involved in Both Seminiferous Cord Formation and Vascular development During Testis Morphogenesis in the Rat. Biol Reprod. 2006 Aug; 75:56-67.
• Anaway MD, AS Cupp, M Uzumcu, MK Skinner. Epigenetic Transgenerational Actions of Endocrine Disruptors on Male Fertility. Science 2005, June 3: 308: 1466-1469.
• Cupp AS , M Uzumcu, H Suzuki, K Dirks, B Phillips, MK Skinner. Effect of Transient embryonic in vivo exposure to the endocrine disruptor methoxychlor on embryonic and postnatal development. J Androl 2003; 24:736-745.
• Kojima FN, Bergfeld EG, Wehrman ME, Cupp AS, Fike KE, Mariscal-Aguayo DV, Sanchez-Torres T, Garcia-Winder M, Clopton DT, Roberts AJ, Kinder JE. Frequency of luteinizing hormone pulses in cattle influences duration of persistence of dominant ovarian follicles, follicular fluid concentrations of steroids, and activity of insulin-like growth factor binding proteins. Animal Reproduction Science. 77(3-4): 187-211, Jul 2003.
• Cupp AS , Uzumcu M, MK Skinner. Chemotactic role of Neurotrophin 3 in the embryonic testis that facilitates male sex determination. Biol. Reprod. 2003 Jun;68(6):2033-7.
• Cupp AS , L Tessarollo, and MK Skinner. Testis development phenotypes in neurotrophin receptor trkA and trkC null mutations: Role in seminiferous cord formation and germ cell survival. Biol. Reprod. 2002;66:1838-1845.
• Cupp AS G Kim, and MK Skinner. Expression and action of Transforming Growth Factor-alpha on embryonic testis growth and development. J. Andrology 2001; 22:1019-1029.
• Cupp AS and Skinner MK. Actions of the endocrine disruptor methoxychlor and its estrogenic metabolite on embryonic seminiferous cord formation and perinatal testis growth. Repro Toxicol 2001; 15:317-326.