Dr. Jennifer Wood's Lab

Dr. Wood's Lab
Picture of Lab Equipment



ASCI 443/843 (Spring) - Physiology of Animal Cells and Tissues:

Undergraduate/Graduate students -3 credit hours; 2015-present

Course Description: The focus of this course is the molecular, cellular, and tissue dependent functions of neurons, skeletal and smooth muscle, vasculature, and immune cells. Cellular regulation of important physiological processes including blood flow, gas exchange, inorganic solute homeostasis, acid-base balance, water balance, appetite control, and thermal regulation will also be studied. At the completion of the course, students should understand cellular and molecular processes that integrate physiological systems in order to ensure homeostasis of the animal.
Role: Course instructor

ASCI 395D and ASCI 499H – Experiential Learning (Research) and Honors Thesis Research:

Undergraduate students –variable credit hours; 2015 –present

Role: Course coordinator – facilitate the identification of faculty with whom students can obtain lab experience (ASCI 395D) or complete undergraduate thesis research (ASCI 499H). Coordinate contracts for the research credits and document grading for each student via their individual instructors



Dr. Wood's Research

PUBMED
Effect of the Follicular Environment on Oocyte Quality
: Anovulation and early embryonic loss is a major contributor to infertility in women and domestic livestock. The success of early embryonic development is dependent, in part, on the quality of the oocyte produced during each reproductive cycle. Furthermore, follicle growth, ovulation, and oocyte quality is dependent on the environment that surrounds the oocyte during its growth and maturation. Thus, a major focus of our research is to identify factors associated with metabolic stress that impair follicle growth and ovulation as well as reduce oocyte quality and determine the mechanism of action of these factors. To attain this goal, our laboratory studies (1) how pro-inflammatory cytokines, metabolic hormones, and the host microbial population regulate mRNA transcription and post-transcriptional processing in the oocyte and surrounding granulosa cells and (2) the etiology and impact of altered theca and granulosa cell steroidogenesis which is a characteristic of metabolic stress on oocyte mRNA abundance. Current models used by our laboratory include mouse models of obesity and a cow model of androgen excess. The impedance of this research is to (1) more effectively treat female infertility particularly in women who are obese and (2) develop reliable markers to identify replacement heifers that will produce three or more offspring.

Regulation of Fetal Programming by Maternal Factors: Metabolic stress negatively impacts the health of viable offspring. For example, the children of obese mothers are at increased risk for birth defects and the development of metabolic syndrome. In domestic livestock species, the in utero environment modifies the expression of important production traits including growth, feed/forage utilization, meat quality, and reproductive efficiency in viable offspring. The major focus of our research is the impact of maternal obesity on cell proliferation and differentiation in the neural tube (motor neurons) and somites (skeletal muscle and adipose tissue). Currently, we are analyzing the novel role of PPAR gamma on neural tube development. Understanding the impact of maternal obesity on the development of childhood and adult obesity and its associated disorders will make a significant impact on human health. Likewise, understanding how to manipulate the in utero environment in order to optimize production traits will improve the profitability of producers.

Dr. Wood's People



Photo Jennifer Wood

Jennifer R Wood

Associate Professor

A224k Animal Science Building
Phone: (402) 472-6437
Fax: (402) 472-6362

CURRENT GRADUATE RESEARCH


Student
Previous Degree
Degree Objective
Graduation
Renee McFee
MS/DVM –Kansas St. U
PhD
Dec 2015
Dissertation: Role of VEGFA on folliculogenesis and assessment of student learning in Animal Physiology

Fang Xie
MS- Texas A&M-Kingsville
PhD
May 2016
Dissertation: Obesity-dependent changes in oocyte mRNA abundance and the effect of excess maternal RNAs on embryonic development
Awards: Molecular Mechanisms of Disease Poster Award (4/2013), SSR Larry Ewing Travel Award (7/2013), IANR Whitmore Travel Award (7/2013)

Andrea McCain
BS –University of Nebraska
MS
Dec 2018

CURRENT UNDERGRADUATE RESEARCH


Student
Degree
Funding
Jenna Rifer
BS-Veterinary and Biomedical Science
UCARE $2,400
 
Anticipated May 2016
ARD Honors $2,500
Research Topic: Impact of Diet-Induced Obesity on Oocyte Quality after the Ovulatory LH Surge; Effect of High Androgen Concentrations on Granulosa Cell 17β-Estradiol Production and Expression of CYP19A1, the Enzyme Regulating 17β-Estradiol Synthesis

Kelsey Timme
BS- Animal Science
UCARE $2,400
 
Anticipated May 2016
 
Research Topic: Consequence of Transcription Factor Overexpression on Oocyte Maturation and Competence for Embryonic Development

Chris Lindeman
BS –Biochemistry
UCARE $2,400
 
Anticipated May 2017
 
Research Topic: mRNA Abundance Causing a Reduction in the Quality of Oocyte Development as a Result of Obesity


Dr. Wood's Publications

Peer-Reviewed
  1. Ozers MS, Hill JJ, Ervin K, Wood JR, Nardulli AM, Royer CA, and Gorski J (1997) Equilibrium binding of estrogen receptor with DNA using fluorescence anisotropy. J Biol Chem, 272(48): 30405-30411, PMID: 9374531
  2. Wood JR, Greene GL, Nardulli AM (1998) Estrogen response elements function as allosteric modulators of estrogen receptor conformation. Mol Cell Biol, 18(4)1927-34, PMCID: PMC121422
  3. Romine LE, Wood JR, Lamia LA, Prendergast P, Edwards DP, Nardulli AM (1998) The high mobility group protein 1 enhances binding of the estrogen receptor DNA binding domain to the estrogen response element., Mol Endocrinol, 12(5)664-74, PMID: 9605929
  4. Kim J, Petz LN, Ziegler YS, Wood JR, Potthoff SJ, Nardulli AM (2000) Regulation of the estrogen-responsive pS2 gene in MCF-7 human breast cancer cells., J Steroid Biochem Mol Biol, 74(4)157-68, PMID: 11162921
  5. Loven MA, Wood JR, Nardulli AM (2001) Interaction of estrogen receptors alpha and beta with estrogen response elements. Mol Cell Endocrinol, 181(1-2)151-63, PMID: 11476949
  6. Wood JR, Likhite VS, Loven MA, Nardulli AM (2001) Allosteric modulation of estrogen receptor conformation by different estrogen response elements. Mol Endocrinol, 15(7)1114-26, PMID: 11435612
  7. Nelson VL, Qin Kn KN, Rosenfield RL, Wood JR, Penning TM, Legro RS, Strauss JF 3rd, McAllister JM (2001) The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome., J Clin Endocrinol Metab, 86(12)5925-33, PMID: 11739466
  8. Wood JR, Strauss JF 3rd (2002) Multiple signal transduction pathways regulate ovarian steroidogenesis. Rev Endocr Metab Disord, 3(1)33-46, PMID: 11883103
  9. Strauss JF 3rd, Wood JR, Christenson LK, McAllister JM (2002) Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS., Mol Cell Endocrinol, 186(2)183-8, PMID: 11900894
  10. Hubner K, Fuhrmann G, Christenson LK, Kehler J, Reinbold R, De La Fuente R, Wood J, Strauss JF 3rd, Boiani M, Scholer HR (2003) Derivation of oocytes from mouse embryonic stem cells., Science, 300(5623)1251-6, PMID: 12730498
  11. Wood JR, Nelson VL, Ho C, Jansen E, Wang CY, Urbanek M, McAllister JM, Mosselman S, Strauss JF 3rd (2003) The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis., J Biol Chem, 278(29)26380-90, PMID: 12734205
  12. Nelson-DeGrave VL, Wickenheisser JK, Cockrell JE, Wood JR, Legro RS, Strauss JF 3rd, McAllister JM (2004) Valproate potentiates androgen biosynthesis in human ovarian theca cells. Endocrinology, 145(2)799-808, PMID: 14576182
  13. Wood JR, Ho CK, Nelson-Degrave VL, McAllister JM, Strauss JF 3rd (2004) The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling, J Reprod Immunol, 63(1): 51-60, PMID: 15284005
  14. Wood JR, Nelson-Degrave VL, Jansen E, McAllister JM, Mosselman S, Strauss JF 3rd (2005) Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects. Physiol Genomics, 20(3): 233-43, PMID: 15598877
  15. Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (2005) Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins., Mol Hum Reprod, 11(4): 307-17, PMID: 15829580
  16. Ho CKM*, Wood JR*, Stewart DR, Ewens K, Ankener W, Wickenheisser J, Nelson-Degrave V, Zhang Z, Legro RS, Dunaif A, McAllister JM, Spielman RS, Strauss JF 3rd (2005) Increased transcription and increased mRNA stability contribute to increased GATA6 mRNA abundance in PCOS theca cells, J Clin Endocrinol Metab, 90(12): 6596-6602, PMID: 16159937 *authors contributed equally to the manuscript
  17. Stewart DR, Dombroski B, Urbanek M, Ankener W, Ewens KG, Wood JR, Legro RS, Strauss JF 3rd, Dunaif A, Spielman RS (2006) Fine mapping of genetic susceptibility to Polycystic Ovary Syndrome on chromosome 19p13.2 and tests for regulatory activity, J Clin Endocrinol Metab, 91(10): 4112-4117, PMID: 16868051
  18. Wood JR, Dumesic DA, Abbott DH, Strauss JF 3rd (2007) Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis, J Clin Endocrinol Metab, 92(2):705-713, PMID: 17148555
  19. Wang H, Ogawa M, Wood JR, Bartolomei MS, Sammel MD, Kusanovic JP, Walsh SW, Romero R, Strauss JF 3rd (2008) Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes, Hum Mol Genet, 17(8):1087-1096, PMID: 18178580
  20. Silva C*, Wood JR*, Salvador L, Kostetskii I, Williams CJ, and Strauss JF 3rd (2009) Expression profile of male germ cell-associated genes in mouse embryonic stem cell cultures treated with all-trans retinoic acid and testosterone, Mol Reprod Dev, 76(1): 11-21, PMCID: PMC2664383 *authors contributed equally to the manuscript
  21. Yang Z, Norwood KA, Kerl JG, and Wood JR (2012) Genes Involved in the Immediate Early Response and Epithelial-Mesenchymal Transition are Regulated by Adipocytokines in the Female Reproductive Tract, Mol Reprod Dev 79(2): 128-137 PMID: 22128093
  22. Mack EM, Smith JE, Kurz SG, and Wood JR (2012) Cyclic AMP dependent regulation of ovulatory response genes is amplified by IGF1 due to synergistic effects on Akt phosphorylation and NFB transcription factors, Reproduction 144(5): 595-602, PMID: 22956516
  23. Tart JK, Johnson RK, Bundy JW, Ferdinand NN, McKnite AM, Wood JR, Miller PS, Rothschild MF, Spangler ML, Garrick DJ, Kachman SD, and Ciobanu DC (2013) Genome-wide prediction of age at puberty and reproductive longevity in sows, Animal Genetics 44(4): 387-397, PMID: 23437861
  24. Pohlmeier WE, Xie F, Kurz SG, Lu N, and Wood JR (2014) Progressive obesity alters the steroidogenic response to ovulatory stimulation and increases the abundance of RNAs stored in the ovulated oocyte, Mol Reprod Dev 81(8): 735-747, PMID:24824196
  25. Baier SR, Nguyen C, Xie F, Wood JR, and Zempleni J (2014) MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers J Nutr 144(10): 1495-1500, PMCID: PMC4162473
  26. Summers AF, Pohlmeier WE, Brauer VM, Sargent KM, Kurz SG, McFee RM, Cushman RA, Cupp AS, and Wood JR (2014). Altered theca gene expression and ovarian follicular development in cows with follicular fluid androgen excess PLoS ONE 9(10) e110683, PMCID: PMC4199720
  27. Cushman RA, Tait Jr. RG, McNeel AK, Forbes ED, Amundson OL, Lents CA, Lindholm-Perry AK, Perry GA, Wood JR, Cupp AS, Smith TPL, Freetly HC, and Bennett GL (2015) A polymorphism in myostatin influences puberty but not fertility in beef heifers, whereas µ-calpain affects first calf birth weight. J Anim Sci 93(1)117-126, PMID: 255568362


Manuscripts under Revision

  1. McFee RM, Artac RA, Gomes RS, Kurz SG, Summers AF, Cushman RA, Wood JR, and Cupp AS (2015). Vascular Endothelial Growth Factor A isoforms are differentially expressed prior to the LH surge, after the LH surge, and in persistent bovine dominant follicles and may be a marker of follicle health. Cell Tissue Res


Manuscripts Submitted

Manuscripts in Preparation

  1. Beede KA, Xie F, Wolf H, Yates DT, and Wood JR (2015) Maternal obesity alters embryonic expression of desmin and peroxisome proliferator-activated receptor gamma and decreases placental expression of 11 beta hydroxysteroid dehydrogenase 2, Dev Biol
  2. Xie F, Anderson CL, Timme KR, Kurz SG, Fernando SC, and Wood JR (2015) Obesity-dependent increases in oocyte-specific mRNAs are associated with increases in pro-inflammatory signaling and gut microbial abundance of Firmicutes , PNAS
  3. McNeel AK, Vallet JL, Snelling WM, Wright EC, Larimore EL, Amundson OL, Miles JR, Chase Jr CC, Lents CA, Sonstegard TE, Schroeder SG, Wood JR, Cupp AS, Perry GA, and Cushman RA (2015) Effects of antral follicle count on endometrial gene expression and uterine function in pubertal beef heifers.

Newsletter and Extension Publications

  1. Wood JR, Dumesic DA, Abbott DH, and Strauss JF 3rd (2007) "Revealing How PCOS Harms Oocyte Competency" in Endocrine News. p10, Ed. C Kristiansen, The Endocrine Society, Chevy Chase, MD, USA
  2. Cushman RA, Wood JR, Slattery RG, Clopton DT, Smith J, Beavers KA, Pohlmeier W, Bergman JW, Moline KV, Cupp AS (2010) Reproductive Ageing Influences Ovarian Function in Beef Cows, Nebraska 2010 Beef Cattle Report, p.16
  3. Cupp AS, Wood JR, McFee R, Slattery RG, Beavers KA, Pohlmeier WE, Sargent KM, Lu N, Smith JE, Brauer VM, Summers AF, Weber SP, and Cushman RA (2011) Granulosa cell gene expression is altered in follicles from cows with differing reproductive longevity, Nebraska 2011 Beef Cattle Report, p 13-15
  4. Lu N*, Smith JE*, Brauer V, Summers A, Pohlmeier W, Beavers KA, McFee R, Sargent K, Kerl JG, Cushman RA, Cupp AS, Wood JR (2012) Oocyte mRNA and Follicle Androgen Levels are Associated with Fertility, Nebraska 2012 Beef Cattle Report, p.28 *authors contributed equally to the manuscript
  5. Wood JR (2012) "The Obesity Epidemic in Women" in Women's Health Overview Newsletter 17(2): 4, Olson Center for Women's Health, University of Nebraska Medical Center
  6. AF Summers, WE Pohlmeier, VM Brauer, KM Sargent, RM McFee, SG Kurz, RA Cushman, JR Wood, AS Cupp (2014). Androgen Excess in Beef Cows Results in Altered Theca Cell Gene Expression and Fertility. Nebraska 2014 Beef Cattle Report p.11
  7. RM McFee, R A Artac, AF Summers, WE Pohlmeier, VM Brauer, SG Kurz, RA Cushman, JR Wood, AS Cupp (2014). Follicular vascular endothelial growth factor A expression before and after the LH surge. Nebraska 2014 Beef Cattle Report p.14
  8. Wood JR (2015). Egg Quality Important for Cows, Women: Research addressing female infertility. Strategic Discussions for Nebraska (in press)
  9. Spuri-Gomes R, Tenley SC, Abedal-Majed MA, Kurz SG, Bergman J, Wood JR, and Cupp AS (2016). Cows with excess androgen are anovulatory and have differing patterns of progesterone secretion. Nebraska 2016 Beef Cattle Report (submitted)
  10. Cupp AS, Romereim S, Summers AF, Pohlmeier WE, McFee RM, Spuri-Gomes R, Kurz SG, McNeel AK, Cushman RA, Davis JS, and Wood JR (2016). Bovine granulosa cell exposure to excess androgens likely inhibits their ability to proliferate which may perpetuate androgen excess. Nebraska 2016 Beef Cattle Report 2016 (submitted)


Book Chapters

  1. Strauss, JF, III, Wood JR, Christenson LK, and McAllister JM (2001) "Does a Genetic Factor Cause Increased Thecal Androgen Secretion in Polycystic Ovary Syndrome?" in Advances in Gynecological Endocrinology, The Processing of the Plenary Sessions of the 8th World Congress of Gynecological Endocrinology. pp. 25-31, Eds AR Genazzani, F Petraglia, PG Artini., Parthenon Publishing.
  2. Wood JR, and Strauss JF 3rd (2007) "Genomics and Polycystic Ovary Syndrome (PCOS): the Use of Microarray Analysis to Identify New Candidate Genes" in Genomics in Endocrinology: DNA Microarray Analysis in Endocrine Health and Disease. pp. 219-238 Eds S Handwerger and B Aronow, Humana Press, Totowa, NJ, USA


Abstracts

  1. Wood JR, McAllister JM, Dunaif A, Urbanek M, Spielman R, and Strauss JF 3rd (2002) Microarray analysis identifies genes with altered expression in PCOS theca, muscle, and adipocyte cells, The Endocrine Society's 84th Annual Meeting, San Francisco, CA
  2. Wood JR, Nelson-Degrave VL, Jansen E, Mosselman S, McAllister JM, and Strauss JF 3rd (2003) Insights into the metabolic side effects of valproic acid revealed from cDNA microarray analysis, The Endocrine Society's 85th Annual Meeting, Philadelphia, PA
  3. Wood JR, Ho C, McAllister JM, Dunaif A, and Strauss JF 3rd (2003) GATA-6, a regulator of Cyp11A and Cyp17 promoter activity, is a PCOS candidate gene, Society for the Study of Reproduction 36th Annual Meeting, Cincinnati, OH
  4. Christenson LK, Wood JR, and Sterneck E (2003) Thecal hypertrophy and enhanced Cyp17 expression in the CCAAT/Enhancer-binding protein  knockout mouse ovary implicate this granulosa cell transcription factor in the regulation of theca cells, Society for the Study of Reproduction 36th Annual Meeting, Cincinnati, OH
  5. Wood JR, Dumesic DA, Abbott DH, Walker DL, and Strauss JF 3rd (2005) Distinct differences in gene expression in polycystic ovary syndrome (PCOS) oocytes, Society for Gynecological Investigation 2005 Annual Meeting, Los Angeles, CA
  6. Ogawa M, Wood JR, Bartolomei MS, and Strauss JF 3rd (2006) Epigenetic factors contribute to the regulation of MMP-1 gene expression in amnion fibroblasts, Society for Gynecological Investigation 2006 Annual Meeting, Toronto, Canada
  7. Zhang Z, Jaimez R, Shen X, Gude D, Tang H, Wood JR, Goldberg E, and Strauss JF 3rd (2008) Autoregulation of SPAG16 expression, a single gene encoding an axoneme structural protein and a transcription factor that activates the axoneme protein promoter, First World Congress on Reproductive Biology, Kona, HI
  8. Cockerill KA, Kerl JG, and Wood JR (2008) Expression of the mitotic kinases Nek2 and Nek4 is coordinately regulated in the ovary during estrus, Society for the Study of Reproduction 41st Annual Meeting, Kona, HI
  9. Wood JR, Yang Z, Mack EM, Cockerill KA, Hofman LA, and Smith JE (2008) Expression profile of MTOC-associated genes and growth factors in the ovary, Nebraska Physiological Society 11th Annual Meeting, Omaha, NE
  10. Slattery R, Clopton D, Wood JR, Cushman R, and Cupp A (2009) Vascular endothelial growth factor (VEGF) mRNA isoforms are altered in bovine granulosa cells (GC) by circulating progestin concentrations (P4) and may indicate follicle status and ooctye competence Midwest Animal Science Annual Meeting (J. Animal Science) 87 (Supp 1) 85
  11. Cushman RA, Wood JR, Echternkamp SE, and Cupp AS (2009) Influence of exogenous progestin on ovarian function in beef cows. Midwest Animal Science Annual Meeting (J. Animal Science) 87 (Supp 1) 239.
  12. Smith JE, Yang Z, Yaw T, and Wood JR (2009) IGF-1 Dependent Changes in Histone H3 Modifications are Associated with Akt Signaling and the Expression of Cell Survival Genes, Biol Reprod 81 (1 Supplement) 144
  13. Mack EM, Smith JE, and Wood JR (2009) Synergistic Activation of Akt by IGF-1 and FSH is Correlated with Altered Expression of Several Granulosa Cell Paracrine Factors that Affect Follicle Progression or Ovulation. 6th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS
  14. Yang Z, Smith JE, Yaw T, and Wood JR (2009) IGF-1 dependent changes in histone H3 modifications are associated with Akt signaling and the expression of cell survival and immediate early genes. 6th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS
  15. Wood JR (2010) The Oocyte Molecular Phenotype: Influence of the Follicular Environment and Body Condition. Midwest Animal Science Annual Meeting
  16. Mack EM, Smith JE, Kerl JG, and Wood JR (2010) Synergistic Activation of Akt by IGF-1 and cAMP is Correlated with Altered Expression of Paracrine Factors that Regulate Follicle Progression and Ovulation in Murine Granulosa Cells, Society for the Study of Reproduction 42nd Annual Meeting, Milwaukee, WI
  17. Smith JE, Mack EM, Kerl JG, Weber SP, and Wood JR (2010) Progressive obesity alters the metabolic hormone profile and molecular phenotype of the female reproductive tract of the Lethal Yellow mouse line. 7th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS
  18. Summers A, Cushman R, Smith JE, Lammers B, McFee R, Pohlmeier W, Brauer V, Sargent K, Lu N, Cupp AS, Wood JR (2011) Females with reduced fertility have excess androstenedione in follicular fluid, altered theca gene expression and increased VEGFA164b, maternal effect, and microRNA processing mRNA levels in cumulus-oocyte complexes, Society for the Study of Reproduction 43rd Annual Meeting, Portland, OR
  19. Wood JR, Yang Z, and Smith JE (2011) Genes involved in the immediate early response and epithelial mesenchymal transition are regulated by adipocytokines in the female reproductive tract, Society for the Study of Reproduction 43rd Annual Meeting, Portland, OR
  20. Summers AF, Cushman RA, Smith JE, Lammers B, McFee R, Pohlmeier WE, Brauer V, Sargent K, Lu N, Cupp AS, and Wood JR (2011) Cows with Reduced Fertility and Granulosa Cell Efficiency have Excess Androstenedione in Follicular Fluid, Altered Theca Gene Expression and Increased Maternal Effect Gene mRNA levels in Cumulus-Oocyte Complexes. 8th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS
  21. Norwood KA, Yang Z, Smith JE, Kerl JG, and Wood JR (2011) Genes involved in the Immediate Early Response and Epithelial-Mesenchymal Transition are Regulated by Adipocytokines in the Female Reproductive Tract. 8th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS
  22. Norwood KA, Brandt AK, and Wood JR (2012) Maternal Obesity Induces Placenta Oxidative Stress and Alters the Differentiation of Mesodermal Cells to the Myogenic versus Adipogenic Lineage. Society for the Study of Reproduction 44th Annual Meeting, State College, PA
  23. Summers AF, Pohlmeier WE, McFee RM, Brauer VM, Kurz S, Cushman RA, Wood JR, and Cupp AS (2012) VEGF164B mRNA Abundance has a Positive Relationship to AMH, BCL2 and the Ratio of E2:A4 in Mural Granulosa Cells of Estrogen Active and Inactive Follicles Prior to Ovulation. Society for the Study of Reproduction 44th Annual Meeting, State College, PA
  24. Khalilzad-Sharghi V, Pohlmeier WE, Tart JK, Greiss RS, Wood JR, and Othman SF (2012) MRE and QPCR indicate Changes in Liver Phenotypes upon Consumption of a High Fat Diet. Biomedical Engineering Society Annual Meeting, Atlanta, GA
  25. Norwood KA, Brandt AK, and Wood JR (2012) Altered Embryonic Expressin of DESMIN and PPARG is Associated with Placental Insufficiency and Increased Placental Oxidative Stress Gene Expression in a Mouse Model of Maternal Obesity. 9th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS
  26. Xie F, Pohlmeier WE, Lu N, Smith JE, McKnite AM, Ciobanu DC, and Wood JR (2013) Genetic background determines the effect of a high fat diet on body weight, ovulation rates, ovarian steroidogenesis, and mRNA abundance of maternal effect genes in ovulated MII-arrested oocytes. Rocky Mountain Reproductive Sciences Symposium, Medical Center of the Rockies, Loveland, CO
  27. Pohlmeier WE, Xie F, Lu N, Smith JE, Wood JR (2013) Progressive obesity alters the steroidogenic response to ovulatory stimulation and increases the abundance of RNAs stored in the MII-arrested oocyte. Rocky Mountain Reproductive Sciences Symposium, Medical Center of the Rockies, Loveland, CO
  28. Xie F, Pohlmeier WE, Lu N, Smith JE, McKnite AM, Ciobanu DC, and Wood JR (2013) Genetic background determines the effect of a high fat diet on body weight, ovulation rates, ovarian steroidogenesis, and mRNA abundance of maternal effect genes in ovulated MII-arrested oocytes. Society for the Study of Reproduction 46th Annual Meeting, Montreal, Quebec, Canada
  29. Pohlmeier WE, Xie F, Lu N, Smith JE, Wood JR (2013) Progressive obesity alters the steroidogenic response to ovulatory stimulation and increases the abundance of RNAs stored in the MII-arrested oocyte. Society for the Study of Reproduction 46th Annual Meeting, Montreal, Quebec, Canada
  30. Summers AF, Pohlmeier WE, Brauer VM, Sargent KM, McFee RM, Cushman RA, Wood JR, and Cupp AS (2013) A bovine model for polycystic ovary syndrome. Society for the Study of Reproduction 46th Annual Meeting, Montreal, Quebec, Canada
  31. McFee RM, Kurz SG, Summers AF, Pohlmeier WE, Wood JR, Cushman RA, and Cupp AS (2013) Granulosa cells activate different signal transduction pathways dependent on follicle health status and ability to convert androstenedione to estrogen resulting in different steroidogenic profiles for beef cattle follicles. Society for the Study of Reproduction 46th Annual Meeting, Montreal, Quebec, Canada
  32. Xie F, Pohlmeier WE, Rifer JL, and Wood JR (2014) Diet-Induced Obesity Increases Basonuclin1, Growth Differentiation Factor 9 and Developmental Pluripotency-Associated Protein 3 mRNAs in Growing Oocytes and Alters Ovarian AKT, ERK and STAT3 Signaling. Society for the Study of Reproduction 47th Annual Meeting, Grand Rapids, MI
  33. Summers AF, Pohlmeier WE, Sargent KM, Kurz SG, McFee RM, McNeel AK, Cushman RA, Wood JR, and Cupp AS (2014) Granulosa Cell Gene Expression Profiling in Cows with Divergent Follicular Fluid Concentrations of Androgens. Society for the Study of Reproduction 47th Annual Meeting, Grand Rapids, MI
  34. Xie F, Timme K, Rifer JL, and Wood JR (2014) Diet-induced obesity increases of Pou5f1 and Dppa3 in growing and mature oocytes are due to increased STAT3 signaling. 11th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS
  35. Romereim S, Summers AF, Pohlmeier WE, McFee R, Spuri-Gomes R, Kurz SG, Cushman RA, Davis JS, Wood JR, and Cupp AS (2014) Differential regulation of cell cycle and immune response networks in bovine granulosa cells with excess intrafollicular androstenedione. 11th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS
  36. Spuri-Gomes R, Tenley SC, Kurz SG, Wood JR, and Cupp AS (2015) Cows with intrafollicular androgen excess have lower sex hormone binding globulin and appear to be chronic or sporadic anovulatory. Society for the Study of Reproduction 48th Annual Meeting, San Juan, Puerto Rico
  37. Romereim SM, Summers AF, Pohlmeier WE, McFee RM, Spuri-Gomes R, Kurz SG, McNeel AK, Cushman RA, Davis JS, Wood JR, and Cupp AS (2015) Granulosa cell cycle regulation and steroidogenesis in a high androstenedione follicular microenvironment. Society for the Study of Reproduction 48th Annual Meeting, San Juan, Puerto Rico
  38. Ayoub M, Manamage M, Vinton R, Cushman RA, McNeel AK, Freetly HC, Wood JR, and Cupp AS (2015) Vascular endothelial growth factor A 165 (VEGFA165), angiogenic isoform, promotes while VEGFA165b antagonizes VEGFA165 stimulated follicular progression in bovine ovarian cortical pieces cultured from pre-pubertal heifers. Society for the Study of Reproduction 48th Annual Meeting, San Juan, Puerto Rico
  39. Xie F, Anderson CL, Timme K, Fernando SC, and Wood JR (2015) Increased Firmicutes in the cecum of obese female mice is correlated with increased Pou5f1 and Dppa3 mRNAs in growing oocytes which may be mediated by increased Toll-like receptor 4 signaling in the ovary. Society for the Study of Reproduction 48th Annual Meeting, San Juan, Puerto Rico
  40. Wood JR, Xie F, Anderson CL, Timme KR, and Fernando SC (2015) The female obese phenotype: increased ovarian inflammation and changes in the gut microbiome regulate the transcription of maternal effect gene mRNAs. Gordon Research Conference: Fertilization and Activation of Development, Holderness, NH


Dr. Wood's Invited Talks and Presentations

Research
  1. Wood JR (12/2014) Departmental Seminar, Animal Science, University of Nebraska-Lincoln; Influence of Ovarian Environment on Oocyte Growth and Maturation: Lessons Learned from Cows and Mice
  2. Wood JR (2/2014) Departmental Seminar, Animal Science, Iowa State University; Ames, IA; Influence of Ovarian Environment on Oocyte Growth and Maturation: Lessons Learned from Cows and Mice
  3. Wood JR (12/2012), Animal Science External Advisory Committee, University of Nebraska-Lincoln; Lincoln, NE; Genomic and Environmental Determinants of Female Fertility and Fetal Development
  4. Wood JR (7/2012), Ag Builders of Nebraska Annual Meeting, US Meat Animal Research Center; Clay Center, NE; Strategies to Improve Heifer Selection and Heifer Development
  5. Wood JR (09/2011), Gilbert Greenwald Symposium (Regional Reproductive Symposia), University of Kansas Medical Center; Kansas City, KS; Effect of an Obese Phenotype on Transcriptional and Post-transcriptional Regulation of Oocyte mRNA Abundance
  6. Wood JR (03/2011), American Society of Animal Science, Midwest Animal Science Meeting Physiology Symposium; Des Moines, IA; The Oocyte Molecular Phenotype: Influence of the Follicular Environment and Body Condition
  7. Wood JR (02/2011), University of Nebraska Medical Center, Dept. Ob/GYN, Grand Rounds; Omaha, NE; PCOS, the Obese Phenotype, and the Regulation of Oocyte Quality
  8. Wood JR (10/2010), Omaha VA Medical Center, Research Seminar; Omaha, NE; Impact of the Maternal Metabolic Profile on Ovarian Function and Embryonic Development
  9. Wood JR (6/2010), University of Nebraska Medical Center, Reproductive Physiology Group Meeting; Omaha, NE; Effect of Obesity on Ovarian Function, Oocyte Quality, and , Embryonic Development
  10. Wood JR (5/2010), Nebraska Gateway to Nutrigenomics, Seminar Speaker; Lincoln, NE; Effect of Obesity on Ovarian Function, Oocyte Quality, and Embryonic Development
  11. Wood JR (2/2009), University of Wyoming Animal Science Departmental Seminar, Seminar Speaker; Laramie, WY; Importance of Good Oocyte-Granulosa Cell Communication for Optimal Oocyte Quality
  12. Wood JR (9/2008), Nebraska Physiological Society, 11th Annual Meeting (Regional Research Meeting); Omaha, NE; Expression Profile of MTOC-Associated Genes and Growth Factors in the Ovary
  13. Wood JR (5/2008), The Fels Institute, Temple University School of Medicine, Research Seminar; Philadelphia, PA; Expression of NIMA-Related Kinases in the Ovary: Do They Influence Oocyte Quality
  14. Wood JR (9/2007), University of Kansas Medical Center, DC Johnson Seminar Series, Seminar Speaker; Kansas City, KS; Regulation of Oocyte Gene Expression: Implications for Oocyte Quality and Embryonic Development
  15. Wood JR (10/2006), US Meat Animal Research Center, Seminar Speaker; Clay Center, NE; The Effect of Disrupted Insulin Signaling on Reproductive Capacity: A Tale of Mice and (Wo)Men

Teaching

  1. Cockerill KA and Wood JR (2/2008) University of Nebraska Regents Campus Visit; Lincoln, NE; Importance of UCARE as a Part of the Undergraduate Educational Experience: Hormones and Regulation of Gene Expression in Mice

Events


Adaptive Programming of Childhood Diseases and Disorders Seminar Series BannerJoin in through adobe connect by clicking here

Maternal obesity, placental function and fetal growth: Can we intervene?
Dr. Theresa Powell, Professor
Dept. of Pediatrics, Division of Neonatology
University of Colorado

October 13th
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Effects of Early-Life Immune Activation on Later-Life Brain and Behavior.
Dr. Jaclyn Schwarz, Assistant Professor
Dept. Psychological & Brain Sciences
University of Delaware

November 17th
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Maternal Obesity and Developmental Programming in the ‘First 1000 Days’ Paradigm
Dr. Kartik Shankar, Associate Professor
Department of Pediatrics
University of Arkansas

December 1st
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Maternal Metabolic Programming in Mouse, Monkey, and Man: Where are the hits coming from and what can we do about it?
Dr. Jed Friedman, Professor
Dept. of Pediatrics, Biochemistry & Molecular Genetics
University of Colorado